ethyl 3-amino-4-(propan-2-ylamino)benzoate
Ethyl 3-amino-4-(isopropylamino)benzoate
CAS: 1187570-89-3
Molecular Formula: C12H18N2O2
ethyl 3-amino-4-(propan-2-ylamino)benzoate - Names and Identifiers
| Name | Ethyl 3-amino-4-(isopropylamino)benzoate |
| Synonyms | Ethyl 3-amino-4-(isopropylamino)benzoate ethyl 3-amino-4-(propan-2-ylamino)benzoate |
| CAS | 1187570-89-3 |
ethyl 3-amino-4-(propan-2-ylamino)benzoate - Physico-chemical Properties
| Molecular Formula | C12H18N2O2 |
| Molar Mass | 222.28 |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD13562404 |
ethyl 3-amino-4-(propan-2-ylamino)benzoate - Risk and Safety
| Hazard Class | IRRITANT |
ethyl 3-amino-4-(propan-2-ylamino)benzoate - Introduction
Ethyl 3-amino-4-(isopropylamino)benzoate is an organic compound with the chemical formula C12H18N2O2.
Its properties are as follows:
1. appearance: colorless to light yellow liquid.
2. Melting point: about 35-40°C.
3. Boiling point: about 285-289°C.
4. density: about 1.06 g/cm.
5. Solubility: Soluble in common organic solvents, such as ethanol, chloroform and dichloromethane.
Primary Use:
1. Ethyl 3-amino-4-(isopropylamino)benzoate is commonly used as a pharmaceutical intermediate for the synthesis of some pharmaceutical compounds.
2. It can also be used as a catalyst in organic synthesis reactions, for example, in C- C bond formation reactions.
Preparation Method:
Ethyl 3-amino-4-(isopropylamino)benzoate can be obtained by reacting 3-amino-4-chlorobenzoic acid with isopropylamine. The specific preparation method is as follows:
3-amino -4-chlorobenzoic acid and isopropylamine are added to anhydrous dimethylformamide in a molar ratio of 1:1.5 for reaction, and the reaction time is about 5-6 hours. The reaction solution was then concentrated, crystallized by rapid cooling, and the solid was filtered and washed with ethyl acetate to give pure product.
Safety Information:
1. Ethyl 3-amino-4-(isopropylamino)benzoate is an organic compound and should avoid contact with skin and eyes.
2. Wear appropriate protective equipment such as gloves and goggles during operation.
3. in case of accidental contact, rinse the affected area with plenty of water immediately and seek medical attention in time.
4. should be stored in a cool, dry place, away from fire and strong oxidants.
Please note that the above information is for reference only. Please operate and handle the compound in accordance with the actual situation and the safe operation procedures of the chemical laboratory.
Its properties are as follows:
1. appearance: colorless to light yellow liquid.
2. Melting point: about 35-40°C.
3. Boiling point: about 285-289°C.
4. density: about 1.06 g/cm.
5. Solubility: Soluble in common organic solvents, such as ethanol, chloroform and dichloromethane.
Primary Use:
1. Ethyl 3-amino-4-(isopropylamino)benzoate is commonly used as a pharmaceutical intermediate for the synthesis of some pharmaceutical compounds.
2. It can also be used as a catalyst in organic synthesis reactions, for example, in C- C bond formation reactions.
Preparation Method:
Ethyl 3-amino-4-(isopropylamino)benzoate can be obtained by reacting 3-amino-4-chlorobenzoic acid with isopropylamine. The specific preparation method is as follows:
3-amino -4-chlorobenzoic acid and isopropylamine are added to anhydrous dimethylformamide in a molar ratio of 1:1.5 for reaction, and the reaction time is about 5-6 hours. The reaction solution was then concentrated, crystallized by rapid cooling, and the solid was filtered and washed with ethyl acetate to give pure product.
Safety Information:
1. Ethyl 3-amino-4-(isopropylamino)benzoate is an organic compound and should avoid contact with skin and eyes.
2. Wear appropriate protective equipment such as gloves and goggles during operation.
3. in case of accidental contact, rinse the affected area with plenty of water immediately and seek medical attention in time.
4. should be stored in a cool, dry place, away from fire and strong oxidants.
Please note that the above information is for reference only. Please operate and handle the compound in accordance with the actual situation and the safe operation procedures of the chemical laboratory.
Last Update：2024-04-09 15:18:09
